Extracellular calcium sensing under normal and pathological conditions
نویسندگان
چکیده
منابع مشابه
The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions.
The calcium-sensing receptor (CaSR) belongs to the evolutionarily conserved family of plasma membrane G protein-coupled receptors (GPCRs). Early studies identified an essential role for the CaSR in systemic calcium homeostasis through its ability to sense small changes in circulating calcium concentration and to couple this information to intracellular signaling pathways that influence parathyr...
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The cloning of a G protein-coupled extracellular Ca(2+) (Ca(o)(2+))-sensing receptor (CaR) has elucidated the molecular basis for many of the previously recognized effects of Ca(o)(2+) on tissues that maintain systemic Ca(o)(2+) homeostasis, especially parathyroid chief cells and several cells in the kidney. The availability of the cloned CaR enabled the development of DNA and antibody probes f...
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ژورنال
عنوان ژورنال: Orvosi Hetilap
سال: 2009
ISSN: 0030-6002,1788-6120
DOI: 10.1556/oh.2009.28602